American guitars are once again being produced, and quality is job 1. Mid Fender opens it's factory in Ensenada, Mexico. Up to Fender continued to employ the FujiGen Gakki Corp to make guitars, although in more and more limited numbers, and mostly only for guitars intended to be sold in the Japanese market. Others say "crafted" had a nicer ring to it than "made", and so the word change was all about marketing and preception, this seems to make solid sense.
Upon entering the city, the Knight of Boreas' companion bade him farewell in silence. For the free-spirited Wolf resented the stone walls and lamplight, and yearned for the open wilds. The Knight of Boreas' heart remained free, though his flesh was inside the prison-like city. Meanwhile, the windborne Wolf roamed the forest in the flesh, while his heart remained loyal to the Knight. The Knight of Boreas rode again to hunt. The Wolf followed his scent into battle. Still one were they, the Wolf and the Knight.
Though one they were, death comes for beasts sooner than men. Laying down his sword as a gravestone, the Knight of Boreas buried the Wolf in the remote countryside. The Knight of Boreas then left the city behind, living instead the wandering life of a lone wolf.
In this analogy Genomics England, by advocating for automated processes in WGS, could be seen as seeking to allow less expert tailors and technology to make up a bespoke suit for the individual — a lower quality product masquerading as the real thing. However, the analogy as set out above does not in my view represent the intentions of Genomics England. It does not seek to create Savile Row suits at a lower cost and of a lower quality, using inferior tailors.
These suits would retail at much lower prices and provide a much faster and more affordable opportunity for those in need of a suit. The slightly reduced quality of the individual suit would be made up for by increasing hugely the numbers of those able to afford a suit; and the quality of each suit, whilst less than that of a bespoke tailored version, will nevertheless be guaranteed to a standard level.
Whilst mass produced products are of course different from individually tailored products, they may still be good products, with variation in design, material and size. Automation also has its own advantages: the production line is consistent; quality control ensure consistency of the final products. And because it is likely to be cheaper, automation is also likely to be a more cost effective means of achieving the same ends.
The move to automation allows products and services to reach those in the population who would not otherwise have previously been able to access them. It is this fundamental change of paradigm that is being proposed by Genomics England. This approach will democratise genomics and make WGS available for all who need it; it will allow physicians across all specialties access to tools that will enable them to participate in the practice of genomic medicine.
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